When the heart loses its nerve: New findings on the interaction of nerves and hearts during aging

When the heart loses its nerve: New findings on the interaction of nerves and hearts during aging   On 25 August 2023 ICR Postdoc Julian Wagner published a new study in the prestigious scientific journal Science on the interaction of nerves and hearts during aging....

Circular RNA circPLOD2 regulates pericyte function

Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4 Simone-Franziska Glaser et al. demonstrate that the hypoxia-regulated circular RNA circPLOD2 controls pericytes function, thereby influencing endothelial network formation....

Malat1 deficiency prevents neonatal heart regeneration

Malat1 deficiency prevents neonatal heart regeneration The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates after an insult during the first week of life. In this first week, heart regeneration is mainly driven by...

Mapping the hypertrophic heart, Nature Cardiovascular Research

Nature Cardiovascular Research 2022: A human cell atlas of the pressure-inducedhypertrophic heart With a interdisciplinary team including clinical experts, bioinformaticians, and molecular biologists, we applied large-scale single-nuclei technologies to construct an...

Ever wondered how energetic deficiency can drive cellular overgrowth?

Science Translational Medicine 2021: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease In response to stress, cardiomyocytes reduce their mitochondrial metabolism and undergo hypertrophy. Before increasing in size, cells can duplicate their...

Increased susceptibility of human endothelial cells to SARS-CoV-2 variants

Basic Research in Cardiology 2021: Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants. In our latest publication The ICVR teamed up with the Frankfurt Department for Virology, guided by Prof. Sandra Cieseck, to explore the...