Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis Abstract BACKGROUND: Pericytes are capillary-associated mural cells involved in the maintenance and stability of the vascular network. Although aging is one of the main risk factors for...
When the heart loses its nerve: New findings on the interaction of nerves and hearts during aging On 25 August 2023 ICR Postdoc Julian Wagner published a new study in the prestigious scientific journal Science on the interaction of nerves and hearts during aging....
Malat1 deficiency prevents neonatal heart regeneration The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates after an insult during the first week of life. In this first week, heart regeneration is mainly driven by...
Nature Cardiovascular Research 2022: A human cell atlas of the pressure-inducedhypertrophic heart With a interdisciplinary team including clinical experts, bioinformaticians, and molecular biologists, we applied large-scale single-nuclei technologies to construct an...
Science Translational Medicine 2021: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease In response to stress, cardiomyocytes reduce their mitochondrial metabolism and undergo hypertrophy. Before increasing in size, cells can duplicate their...
