Malat1 deficiency prevents neonatal heart regeneration The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates after an insult during the first week of life. In this first week, heart regeneration is mainly driven by...
Nature Cardiovascular Research 2022: A human cell atlas of the pressure-inducedhypertrophic heart With a interdisciplinary team including clinical experts, bioinformaticians, and molecular biologists, we applied large-scale single-nuclei technologies to construct an...
Science Translational Medicine 2021: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease In response to stress, cardiomyocytes reduce their mitochondrial metabolism and undergo hypertrophy. Before increasing in size, cells can duplicate their...
Basic Research in Cardiology 2021: Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants. In our latest publication The ICVR teamed up with the Frankfurt Department for Virology, guided by Prof. Sandra Cieseck, to explore the...
nature communications 2021: Post-myocardial infarction heart failure dysregulates the bone vascular niche Clinicians and basic scientists from the Cardiology Department and Institute of Cardiovascular Regeneration described the response of the bone cell composition to...
Circulation 2021: Specific diagnosis and therapy for children with heart failure The pathological dilation of the heart muscle could have different characteristics in young patients and should therefore be treated individually. This is the result of a study conducted...
