Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation Abstract: Aims Cardiovascular disease is the leading cause of death in the European Union and ageing is one of its major risk factors resulting in the...
Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart Abstract: Aims Members of the VEGF family are crucial modulators of vascular and neural function. While VEGFA signalling has been shown to mitigate several aging-related...
Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction Abstract: BACKGROUND: Endothelial cells (ECs) play pivotal roles in maintaining cardiac blood supply and regulating inflammation by acting as gatekeepers for immune cell...
STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence Abstract: Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure cases and is characterised by reduced...
Mosaic loss of Y chromosome and mortality after coronary angiography Abstract: Background and aims: Acquired somatic mutations emerged as important drivers of adverse cardiovascular disease outcomes. Recently, mosaic loss of Y chromosome (LOY) in haematopoietic cells...
Inhibition of miR-92a normalizes vascular gene expression and prevents diastolic dysfunction in heart failure with preserved ejection fraction Abstract: Highlights Inhibition miR-92a ameliorates diastolic dysfunction and left atrial enlargement in HFpEF hearts....
