Research Topics

Cellular heterogeneity in cardiovascular regeneration and repair

The heart consists of a multitude of different specialized cells, which communicate with each other to ensure a proper cardiac function every second of our life. If the heart gets injured, for example after a heart attack (myocardial infarction) or in heart failure due to chronic disease, the roles and phenotypes of these specialized cells can profoundly change…

Molecular mechanisms of cardiovascular IncRNAs & RNA therapeutics

Non-coding RNAs (ncRNAs) are ribonucleic acid molecules that are not translated into proteins. Instead, they modulate complex molecular and cellular processes, for example gene expression, RNA maturation, and protein synthesis. In our team, we are interested in the molecular function of long non-coding RNAs (lncRNAs) and their implication in the cardiovascular system…

The vascular niche in aging

Cardiovascular disease (CVD) is the leading cause of death in the EU accounting for 37% of all deaths and furthermore, ageing is a major risk factor of these diseases. Ageing results in the progressive deterioration of the cardiac structures and compromises heart function. Although the phenotypes that arise from cardiac aging have been profoundly described, the molecular mechanisms that drive these pathological processes are just beginning to be explored…

Clonal hematopoeisis and inflammatory mechanisms in cardiovascular disease

Cardiovascular diseases (CVD) are the manifestations of chronic inflammation facilitated by aging, diabetes, dyslipidemia, hypertension, and smoking. These conditions promote atherosclerosis and fibrosis in the heart. Utilization of anti-inflammatory therapeutics can decrease death and mortality from cardiovascular disease and slow progression of heart failure…