Publications

Publications 2020

 

Mapping the Endothelial Cell Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function  

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I.

Circulation. 2020 Dec 14. doi: 10.1161/CIRCULATIONAHA.120.051877.

 

Leaders in Cardiovascular Research: Stefanie Dimmeler.

Guzik TJ, Dimmeler S.

Cardiovasc Res. 2020 Dec 1;116(14):e202-e204. doi: 10.1093/cvr/cvaa317.

 

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes.

Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S.

Cardiovasc Res. 2020 Dec 1;116(14):2207-2215. doi: 10.1093/cvr/cvaa267.

 

Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry.

Cremer S, Jakob C, Berkowitsch A, Borgmann S, Pilgram L, Tometten L, Classen A, Wille K, Weidlich S, Gruener B, Dimmeler S, Massberg S, Rieg S, Zeiher AM; LEOSS study group.

Clin Res Cardiol. 2020 Nov 19:1–12. doi: 10.1007/s00392-020-01769-9.

 

Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ.

Zehendner CM, Valasarajan C, Werner A, Boeckel JN, Bischoff FC, John D, Weirick T, Glaser SF, Rossbach O, Jaé N, Demolli S, Khassafi F, Yuan K, de Jesus Perez VA, Michalik KM, Chen W, Seeger W, Guenther A, Wasnick RM, Uchida S, Zeiher AM, Dimmeler S, Pullamsetti SS.

Am J Respir Crit Care Med. 2020 Nov 15;202(10):1445-1457. doi: 10.1164/rccm.201910-2041OC.

 

Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.

Abplanalp WT, Cremer S, John D, Hoffmann J, Schuhmacher B, Merten M, Rieger MA, Vasa-Nicotera M, Zeiher AM, Dimmeler S.

 Circ Res. 2021 Jan 22;128(2):216-228. doi: 10.1161/CIRCRESAHA.120.317104.

 

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.

Bär C, Chatterjee S, Falcão Pires I, Rodrigues P, Sluijter JPG, Boon RA, Nevado RM, Andrés V, Sansonetti M, de Windt L, Ciccarelli M, Hamdani N, Heymans S, Figuinha Videira R, Tocchetti CG, Giacca M, Zacchigna S, Engelhardt S, Dimmeler S, Madonna R, Thum T.

Cardiovasc Res. 2020 Sep 1;116(11):1805-1819. doi: 10.1093/cvr/cvaa195. PMID: 32638021.

 

Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study. Nucleic

Abplanalp WT, Fischer A, John D, Zeiher AM, Gosgnach W, Darville H, Montgomery R, Pestano L, Allée G, Paty I, Fougerousse F, Dimmeler S. Acid Ther. 2020 Dec;30(6):335-345. doi: 10.1089/nat.2020.0871.

 

Inflammatory signatures are associated with increased mortality after transfemoral transcatheter aortic valve implantation.

Hoffmann J, Mas-Peiro S, Berkowitsch A, Boeckling F, Rasper T, Pieszko K, De Rosa R, Hiczkiewicz J, Burchardt P, Fichtlscherer S, Zeiher AM, Dimmeler S, Nicotera MV ESC Heart Fail. 2020 Oct;7(5):2597-2610. doi: 10.1002/ehf2.12837.

 

Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure.

Abplanalp WT, Mas-Peiro S, Cremer S, John D, Dimmeler S, Zeiher AM. JAMA Cardiol. 2020 Jul 8;5(10):1–6. doi: 10.1001/jamacardio.2020.2468.

 

Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue.

Jakobi T, Siede D, Eschenbach J, Heumüller AW, Busch M, Nietsch R, Meder B, Most P, Dimmeler S, Backs J, Katus HA, Dieterich C. Cells. 2020 Jul 4;9(7):1616. doi: 10.3390/cells9071616.

 

Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated With Increased Mortality in Patients With Chronic Heart Failure.

Cremer S, Kirschbaum K, Berkowitsch A, John D, Kiefer K, Dorsheimer L, Wagner J, Rasper T, Abou-El-Ardat K, Assmus B, Serve H, Rieger M, Dimmeler S, Zeiher AM. Circ Genom Precis Med. 2020 Aug;13(4):e003003. doi: 10.1161/CIRCGEN.120.003003.

 

Circulating Th17 and Th22 Cells Are Associated With CMR Imaging Biosignatures of Diffuse Myocardial Interstitial Remodeling in Chronic Coronary Artery Disease.

Hoffmann J, Puntmann VO, Fišer K, Rasper T, Berkowitsch A, Carerj ML, Nagel E, Dimmeler S, Zeiher AM. Circ Res. 2020 Aug 14;127(5):699-701. doi: 10.1161/CIRCRESAHA.120.316619.

 

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function.

Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon HB, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Commun Biol. 2020 May 26;3(1):265. doi: 10.1038/s42003-020-0987-0.

 

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts.

Nicin L, Abplanalp WT, Mellentin H, Kattih B, Tombor L, John D, Schmitto JD, Heineke J, Emrich F, Arsalan M, Holubec T, Walther T, Zeiher AM, Dimmeler S. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Eur Heart J. 2020 May 14;41(19):1804-1806. doi: 10.1093/eurheartj/ehaa311.

 

Aging- regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.

Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Aging- regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020 Apr 27;11(1):2039. doi: 10.1038/s41467-020-15995-2.

 

Noncoding RNAs in Vascular Diseases.

Jaé N, Dimmeler S. Circ Res. 2020 Apr 24;126(9):1127-1145. doi: 10.1161/CIRCRESAHA.119.315938.

 

The Institute of Cardiovascular Regeneration.

Dimmeler S, Schulenburg K. Eur Heart J. 2020 Apr 21;41(16):1533-1535. doi: 10.1093/eurheartj/ehaa120.

 

An epidemiological study exploring a possible impact of treatment with ACE inhibitors or angiotensin receptor blockers on ACE2 plasma concentrations.

Wild PS, Dimmeler S, Eschenhagen T. J Mol Cell Cardiol. 2020 Apr;141:108-109. doi: 10.1016/j.yjmcc.2020.03.018. Epub 2020 Apr 5.

 

Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation.

Mas-Peiro S, Hoffmann J, Fichtlscherer S, Dorsheimer L, Rieger MA, Dimmeler S, Vasa-Nicotera M, Zeiher AM. Eur Heart J. 2020 Feb 21;41(8):933-939. doi: 10.1093/eurheartj/ehz591.

 

The histone demethylase JMJD2B regulates endothelial-to- mesenchymal transition.

Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4180-4187. doi: 10.1073/pnas.1913481117.

 

Parallel Lineage- Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor.

Cattaneo P, Mukherjee D, Spinozzi S, Zhang L, Larcher V, Stallcup WB, Kataoka H, Chen J, Dimmeler S, Evans SM, Guimarães-Camboa N. Cell Rep. 2020 Jan 14;30(2):571-582.e2. doi: 10.1016/j.celrep.2019.12.046.

 

Clonal hematopoiesis, aging, and cardiovascular diseases.

Pardali E, Dimmeler S, Zeiher AM, Rieger MA. Exp Hematol. 2020 Mar;83:95-104. doi: 10.1016/j.exphem.2019.12.006.

 

Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics.

Wagner JUG, Pham MD, Nicin L, Hammer M, Bottermann K, Yuan T, Sharma R, John D, Muhly-Reinholz M, Tombor L, Hardt M, Madl J, Dimmeler S, Krishnan J. J Mol Cell Cardiol. 2020 Jan;138:269-282. doi: 10.1016/j.yjmcc.2019.12.005.

 

Cellular cross-talks in the diseased and aging heart

Wagner JUG, Dimmeler S.. J Mol Cell Cardiol. 2020 Jan;138:136-146. doi: 10.1016/j.yjmcc.2019.11.152.

 

Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.

Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Abou-El-Ardat K, Kiefer KC, Hoffmann J, Seeger F, Bonig H, Dimmeler S, Zeiher AM, Rieger MA. Haematologica. 2020 Jul;105(7):e328-e332. doi: 10.3324/haematol.2019.224402. Epub 2019 Nov 7. PMID: 31699791; PMCID: PMC7327645.