Publications 2023

• The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males.

Rogala S, Ali T, Melissari MT, Währisch S, Schuster P, Sarre A, Emídio RC, Boettger T, Rogg EM, Kaur J, Krishnan J, Dumbović G, Dimmeler S, Ounzain S, Pedrazzini T, Herrmann BG, Grote P. Nat Commun. 2023 Nov, 2;14(1):7024. doi: 10.1038/s41467-023-42760-y. PMID: 37919291; PMCID: PMC10622434.

• Single-nuclear transcriptome profiling identifies persistent fibroblast activation in hypertrophic and failing human hearts of patients with longstanding disease.

Kattih B, Boeckling F, Shumliakivska M, Tombor L, Rasper T, Schmitz K, Hoffmann J, Nicin L, Abplanalp WT, Carstens DC, Arsalan M, Emrich F, Holubec T, Walther T, Puntmann VO, Nagel E, John D, Zeiher AM, Dimmeler S. Cardiovasc Res. 2023 Aug 30:cvad140. doi: 10.1093/cvr/cvad140. Epub ahead of print. PMID: 37648651.

• When the heart loses its nerve: New findings on the interaction of nerves and hearts during aging

Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klöcker N, Kelm M, Schüttler D, Clauss S, Günther S, Boettger T, Braun T, Bär C, Pham MD, Krishnan J, Hille S, Müller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxán G, Dimmeler S. Aging impairs the neurovascular interface in the heart. Science. 2023 Aug 25;381(6660):897-906. doi: 10.1126/science.ade4961. Epub 2023 Aug 24. PMID: 37616346.

• Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential(CHIP) Mutations invade Human Atherosclerotic Plaques.

von Scheidt M, Bauer S, Ma A, Hao K, Kessler T, Vilne B, Wang Y, Hodonsky CJ, Ghosh SKB, Mokry M, Gao H, Kawai K, Sakamoto A, Kaiser J, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Moggio A, Sager HB, Hecker JS, Bassermann F, Maegdefessel L, Miller CL, Koenig W, Zeiher AM, Dimmeler S, Graw M, Braun C, Ruusalepp A, Leeper NJ, Kovacic JC, Björkegren JLM, Schunkert H.medRxiv. 2023 Jul 26:2023.07.22.23292754. doi: 10.1101/2023.07.22.23292754. Preprint.PMID: 37546840

• CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes.

Zhu C, Baumgarten N, Wu M, Wang Y, Das AP, Kaur J, Ardakani FB, Duong TT, Pham MD, Duda M, Dimmeler S, Yuan T, Schulz MH, Krishnan J.Hum Genomics. 2023 Jul 25;17(1):69. doi: 10.1186/s40246-023-00513-4.PMID: 37491351

• Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4.

Glaser SF, Brezski A, Baumgarten N, Klangwart M, Heumüller AW, Maji RK, Leisegang MS, Guenther S, Zehendner CM, John D, Schulz MH, Zarnack K, Dimmeler S.Cell Rep. 2023 Jul 21;42(8):112824. doi: 10.1016/j.celrep.2023.112824. Online ahead of print.PMID: 37481725

• Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning.

Zhou Q, Boeckel JN, Yao J, Zhao J, Bai Y, Lv Y, Hu M, Meng D, Xie Y, Yu P, Xi P, Xu J, Zhang Y, Dimmeler S, Xiao J.MedComm (2020). 2023 Jun 13;4(3):e299. doi: 10.1002/mco2.299. eCollection 2023 Jun.PMID: 37323876

• Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure.

Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, Đikić I, Dimmeler S, Geisslinger G, Greten FR, Hermann E, Hildt E, Kempf VAJ, Klein S, Koch I, Mühl H, Müller V, Peiffer KH, Kestner RI, Piiper A, Rohde G, Scholich K, Schulz MH, Storf H, Toptan T, Vasa-Nicotera M, Vehreschild MJGT, Weigert A, Wild PJ, Zeuzem S, Engelmann C; ACLF-I Investigators,; Schaefer L, Welsch C, Trebicka J.Am J Physiol Cell Physiol. 2023 Jul 1;325(1):C129-C140. doi: 10.1152/ajpcell.00101.2023. Epub 2023 Jun 5.PMID: 37273239

• The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation.

Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K.Immunity. 2023 May 9;56(5):979-997.e11. doi: 10.1016/j.immuni.2023.03.021. Epub 2023 Apr 25.PMID: 37100060

• Cardiomyocyte hyperplasia and immaturity but not hypertrophy are characteristic features of patients with RASopathies.

Drenckhahn JD, Nicin L, Akhouaji S, Krück S, Blank AE, Schänzer A, Yörüker U, Jux C, Tombor L, Abplanalp W, John D, Zeiher AM, Dimmeler S, Rupp S.J Mol Cell Cardiol. 2023 May;178:22-35. doi: 10.1016/j.yjmcc.2023.03.003. Epub 2023 Mar 21.PMID: 36948385

• Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement.

Mas-Peiro S, Abplanalp WT, Rasper T, Berkowitsch A, Leistner DM, Dimmeler S, Zeiher AM.Eur Heart J. 2023 Jun 1;44(21):1943-1952. doi: 10.1093/eurheartj/ehad093.PMID: 36932691

• The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.

Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank D, Franke T, Frey N, Friede T, Geidel L, Germans L, Grabmaier U, Halle M, Hausleiter J, Jakobi V, Jebran AF, Jobs A, Kääb S, Karakas M, Katus HA, Klatt A, Knosalla C, Krebser J, Landmesser U, Lee M, Lehnert K, Lesser S, Leyh K, Lorbeer R, Mach-Kolb S, Meder B, Nagel E, Nolte CH, Parwani AS, Petersmann A, Puls M, Rau H, Reiser M, Rienhoff O, Scharfe T, Schattschneider M, Scheel H, Schnabel RB, Schuster A, Schmitt B, Seidler T, Seiffert M, Stähli BE, Stas A, J Stocker T, von Stülpnagel L, Thiele H, Wachter R, Wakili R, Weis T, Weitmann K, Wichmann HE, Wild P, Zeller T, Hoffmann W, Zeisberg EM, Zimmermann WH, Krefting D, Kühne T, Peters A, Hasenfuß G, Massberg S, Sommer T, Dimmeler S, Eschenhagen T, Nauck M.Clin Res Cardiol. 2023 Jul;112(7):923-941. doi: 10.1007/s00392-023-02177-5. Epub 2023 Mar 8.PMID: 36884078

• Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation.

Aslan GS, Jaé N, Manavski Y, Fouani Y, Shumliakivska M, Kettenhausen L, Kirchhof L, Günther S, Fischer A, Luxán G, Dimmeler S.JCI Insight. 2023 Mar 8;8(5):e162124. doi: 10.1172/jci.insight.162124.PMID: 36883566

• Acute injury to the mouse carotid artery provokes a distinct healing response.

Warwick T, Buchmann GK, Pflüger-Müller B, Spaeth M, Schürmann C, Abplanalp W, Tombor L, John D, Weigert A, Leo-Hansmann M, Dimmeler S, Brandes RP.Front Physiol. 2023 Feb 7;14:1125864. doi: 10.3389/fphys.2023.1125864. eCollection 2023.PMID: 36824462

• Long-term risk associated with clonal hematopoiesis in patients with severe aortic valve stenosis undergoing TAVR.

Mas-Peiro S, Pergola G, Berkowitsch A, Meggendorfer M, Rieger MA, Vasa-Nicotera M, Dimmeler S, Zeiher AM.Clin Res Cardiol. 2023 May;112(5):585-593. doi: 10.1007/s00392-022-02135-7. Epub 2023 Jan 21.PMID: 36680616

• Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform.

Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, Olmer R, Martin U, Vondran FWR, Toptan T, Rothweiler F, Zehner R, Rabenau HF, Osman KL, Pullan ST, Carroll MW, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr.iScience. 2023 Feb 17;26(2):105944. doi: 10.1016/j.isci.2023.105944. Epub 2023 Jan 7.PMID: 36644320

• Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1⁺T lymphocyte niches through a feed-forward loop.

Hua Y, Vella G, Rambow F, Allen E, Martinez AA, Duhamel M, Takeda A, Jalkanen S, Junius S, Smeets A, Nittner D, Dimmeler S, Hehlgans T, Liston A, Bosisio FM, Floris G, Laoui D, Hollmén M, Lambrechts D, Merchiers P, Marine JC, Schlenner S, Bergers G.Cancer Cell. 2023 Jan 9;41(1):226. doi: 10.1016/j.ccell.2022.12.006.PMID: 36626867

• Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia.

de Oliveira Freitas Machado C, Schafranek M, Brüggemann M, Hernández Cañás MC, Keller M, Di Liddo A, Brezski A, Blümel N, Arnold B, Bremm A, Wittig I, Jaé N, McNicoll F, Dimmeler S, Zarnack K, Müller-McNicoll M.Nucleic Acids Res. 2023 Jan 25;51(2):870-890. doi: 10.1093/nar/gkac1225.PMID: 36620874