Publications
Selected Publications

Publications 2021


Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease
Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J. Sci Transl Med. 2021 Dec 8;13(623):eabi7964. doi: 10.1126/scitranslmed.abi7964. Epub 2021 Dec 8. PMID: 34878823.

Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Response
Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S. s. Circ Res. 2021 Nov 18. doi: 10.1161/CIRCRESAHA.121.320029. Epub ahead of print. PMID: 34789007.

Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart.

Nicin L, Wagner JUG, Luxán G, Dimmeler S. FEBS Lett. 2021 Nov 17. doi: 10.1002/1873-3468.14234. Online ahead of print. PMID: 34787896

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.

Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M.  Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. PMID: 34675436; PMCID: PMC8553622.

 

Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease.

Cremer S, Pilgram L, Berkowitsch A, Stecher M, Rieg S, Shumliakivska M, Bojkova D, Wagner JUG, Aslan GS, Spinner C, Luxán G, Hanses F, Dolff S, Piepel C, Ruppert C, Guenther A, Rüthrich MM, Vehreschild JJ, Wille K, Haselberger M, Heuzeroth H, Hansen A, Eschenhagen T, Cinatl J, Ciesek S, Dimmeler S, Borgmann S, Zeiher A; LEOSS study group. PLoS One. 2021 Oct 21;16(10):e0258684. doi: 10.1371/journal.pone.0258684. eCollection 2021. PMID: 34673795 Free PMC article.

 

LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition.

Pham TP, van Bergen AS, Kremer V, Glaser SF, Dimmeler S, Boon RA. Int J Mol Sci. 2021 Jul 28;22(15):8088. doi: 10.3390/ijms22158088. PMID: 34360851 Free PMC article.

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants.

Wagner JUG, Bojkova D, Shumliakivska M, Luxán G, Nicin L, Aslan GS, Milting H, Kandler JD, Dendorfer A, Heumueller AW, Fleming I, Bibli SI, Jakobi T, Dieterich C, Zeiher AM, Ciesek S, Cinatl J, Dimmeler S.  Basic Res Cardiol. 2021 Jul 5;116(1):42. doi: 10.1007/s00395-021-00882-8.

Post-myocardial infarction heart failure dysregulates the bone vascular niche.

Hoffmann J, Luxán G, Abplanalp WT, Glaser SF, Rasper T, Fischer A, Muhly-Reinholz M, Potente M, Assmus B, John D, Zeiher AM, Dimmeler S.  Nat Commun. 2021 Jun 25;12(1):3964. doi: 10.1038/s41467-021-24045-4. 

Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.

Kiefer KC, Cremer S, Pardali E, Assmus B, Abou-El-Ardat K, Kirschbaum K, Dorsheimer L, Rasper T, Berkowitsch A, Serve H, Dimmeler S, Zeiher AM, Rieger MA.  ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. 

The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice

Buchmann GK, Schürmann C, Spaeth M, Abplanalp W, Tombor L, John D, Warwick T, Rezende F, Weigert A, Shah AM, Hansmann ML, Weissmann N, Dimmeler S, Schröder K, Brandes RP. . Redox Biol. 2021 Jun 18;45:102050. doi: 10.1016/j.redox.2021.102050. 

Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry.

Cremer S, Jakob C, Berkowitsch A, Borgmann S, Pilgram L, Tometten L, Classen A, Wille K, Weidlich S, Gruener B, Dimmeler S, Massberg S, Rieg S, Zeiher AM; LEOSS study group.  Clin Res Cardiol. 2021 Jul;110(7):1029-1040. doi: 10.1007/s00392-020-01769-9. 

Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis.

Gatsiou A, Georgiopoulos G, Vlachogiannis NI, Pfisterer L, Fischer A, Sachse M, Laina A, Bonini F, Delialis D, Tual-Chalot S, Zormpas E, Achangwa R, Jiang L, Kontogiannis C, Patras R, Hermeking H, Zeiher AM, Stamatelopoulos K, Dimmeler S, Stellos K. Atherosclerosis. 2021 Jun;327:49-58. doi: 10.1016/j.atherosclerosis.2021.05.005. 

Single Nuclei Sequencing Reveals Novel Insights Into the Regulation of Cellular Signatures in Children With Dilated Cardiomyopathy.

Nicin L, Abplanalp WT, Schänzer A, Sprengel A, John D, Mellentin H, Tombor L, Keuper M, Ullrich E, Klingel K, Dettmeyer RB, Hoffmann J, Akintuerk H, Jux C, Schranz D, Zeiher AM, Rupp S, Dimmeler S.  Circulation. 2021 Apr 27;143(17):1704-1719. doi: 10.1161/CIRCULATIONAHA.120.051391. 

Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. Circulation. 2021 Mar 2;143(9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877. 

The vasculature: a therapeutic target in heart failure?

Luxán G, Dimmeler S.  Cardiovasc Res. 2021 Feb 23:cvab047. doi: 10.1093/cvr/cvab047. 

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.  

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly- Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S. Nat Commun. 2021 Jan 29;12(1):681. doi: 10.1038/s41467-021-20905-1.

 

Single-cell RNA- sequencing reveals profound changes in circulating immune cells in patients with heart failure.

Abplanalp WT, John D, Cremer S, Assmus B, Dorsheimer L, Hoffmann J, Becker- Pergola G, Rieger MA, Zeiher AM, Vasa-Nicotera M, Dimmeler S. Cardiovasc Res. 2021 Jan 21;117(2):484-494. doi: 10.1093/cvr/cvaa101.

 

Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.

Assmus B, Cremer S, Kirschbaum K, Culmann D, Kiefer K, Dorsheimer L, Rasper T, Abou-El-Ardat K, Herrmann E, Berkowitsch A, Hoffmann J, Seeger F, Mas-Peiro S, Rieger MA, Dimmeler S, Zeiher AM. Eur Heart J. 2021 Jan 20;42(3):257-265. doi: 10.1093/eurheartj/ehaa845.

 

Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function.

Pham TP, Bink DI, Stanicek L, van Bergen A, van Leeuwen E, Tran Y, Matic L, Hedin U, Wittig I, Dimmeler S, Boon RA. Front Cell Dev Biol. 2021 Jan 11;8:619079. doi: 10.3389/fcell.2020.619079.

 

Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.

Abplanalp WT, Cremer S, John D, Hoffmann J, Schuhmacher B, Merten M, Rieger MA, Vasa-Nicotera M, Zeiher AM, Dimmeler S. Circ Res. 2021 Jan 22;128(2):216-228. doi: 10.1161/CIRCRESAHA.120.317104.