Circulation Research 2021: Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incidence of cardiovascular disease and poor...
Nature Communications: Endothelial cells show transient mesenchymal phenotype after infarct Endothelial cells show a remarkable plasticity after myocardial infarction and have critical roles in tissue adaption upon injury. In this study, appearing in Nature...
A research group from Goethe University and University Hospital Frankfurt was able to show that an inhibitor against microRNA-92a is effective in humans. The clinical study was supported by the German Center for Cardiovascular Research (DZHK). The microRNA therapy...
ACE2 is a protein on the surface of cells and serves as the entry gate for the SARS-CoV-2 coronavirus. A Frankfurt research group was able to show that ACE2 is significantly increased in tissue samples from patients with cardiovascular diseases. COVID-19 disease...
We are excited to share that our collaborative work on “Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart” from Vidal and Wagner et. al. has been publishedin JCI Insight...
