Krischnan Group

RNA and Metabolism

General scientific objectives:

Our lab applies integrated epigenomics, transcriptomics and metabolomics to understand the mechanistic intersect of non-coding RNA signaling with mitochondrial and cellular metabolic reprogramming in cardiac pathology. We are focused on understanding the spatio-temporal dynamics, function and mechanistic underpinning of micro RNAs, enhancer-templated RNAs and a novel class of cryptic RNAs in cardiomyopathy. The overarching aim of all our studies is the identification and development of clinically relevant therapeutic agents for the treatment of human heart disease. To that end we utilize human cardiomyocytes and in vivo genetic models of human congenital disease, as our experimental platform, in combination with adeno-associated virus (AAV) and anti-sense RNAs as therapeutic agents.