Research Topics

MicroRNAs

MicroRNAs are small non-coding RNAs, which posttranscriptionally regulate mRNA degradation and protein translation. During the last decade the contribution of microRNAs ….. >>

LncRNAs in Cardio-pulmonary Development

Embryogenesis and resultant organ development is a tightly controlled process intrinsically programmed into the genomes of organisms. >>

Pericytes

Pericytes are perivascular cells that ensheath the endothelium in all major organ systems on the level of the microvasculature. In angiogenesis, pericyte recruitment is…. >>

Lncrnas

In the last years it has become evident that the majority of the genome is transcribed, although only about 2% codes for proteins. Beside microRNAs, long non-coding RNAs (lncRNAs) gained increasing attention as  >>

RNA metabolism and Vascular Inflammation

Despite the current evidence-based guidelines on clinical practice of cardiovascular medicine, the clinical manifestations of atherosclerotic disease remain the major causes of morbidity and mortality.  >>

RNA and Metabolism

Our lab applies integrated epigenomics, transcriptomics and metabolomics to understand the mechanisticintersect of non-coding RNA signaling with mitochondrial and cellular ….  >>

Cardiovascular Repair and Regeneration

The Institute for Cardiovascular Regeneration focuses on the identification of physiological and pathophysiological tissue repair and remodeling processes. Specifically,…. >>

Epigenetics

Epigenetic regulation of gene expression was shown to be involved in many biological processes, including embryonic development and disease conditions. Jumonji C (JmjC) domain-containing…. >>

Non-coding RNA and aging

We aim to unravel the role of non-coding RNAs in the process of aging of the cardiovascular system. Both long and short (microRNAs) non-coding RNAs are emerging as key  >>

Cardiovascular-Bioinformatics

A series of articles by “Functional Annotation Of Mammalian genome (FANTOM)” projects, “ENCyclopedia Of DNA Elements (ENCODE)” consortium, and others…. >>