The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

LncRNAs influence endothelial cell function via a number of mechanisms. Here we show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis.