Inhibition of miR-92a normalizes vascular gene expression and prevents diastolic dysfunction in heart failure with preserved ejection fraction Abstract: Highlights Inhibition miR-92a ameliorates diastolic dysfunction and left atrial enlargement in HFpEF hearts....
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis Abstract BACKGROUND: Pericytes are capillary-associated mural cells involved in the maintenance and stability of the vascular network. Although aging is one of the main risk factors for...
When the heart loses its nerve: New findings on the interaction of nerves and hearts during aging On 25 August 2023 ICR Postdoc Julian Wagner published a new study in the prestigious scientific journal Science on the interaction of nerves and hearts during aging....
Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4 Simone-Franziska Glaser et al. demonstrate that the hypoxia-regulated circular RNA circPLOD2 controls pericytes function, thereby influencing endothelial network formation....
Malat1 deficiency prevents neonatal heart regeneration The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates after an insult during the first week of life. In this first week, heart regeneration is mainly driven by...
Nature Cardiovascular Research 2022: A human cell atlas of the pressure-inducedhypertrophic heart With a interdisciplinary team including clinical experts, bioinformaticians, and molecular biologists, we applied large-scale single-nuclei technologies to construct an...
