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Publications

Top 15 Publications

A coalition to heal-the impact of the cardiac microenvironment.

Tzahor E, Dimmeler S. Science. 2022 Sep 2;377(6610):eabm4443.doi: 10.1126/science.abm 4443. Epub 2022 Sep 2.PMID: 36048959 Review.

The atlas of the hypertrophied heart.                 

Nicin, S. M. Schroeter, S. Glaser, R. Schulze-Brüning, M.-D. Pham, S. S. Hille, , K. Badder, W. T. Abplanalp, L. Tombor, O. J. Müller, M. Yekelchyk, T. Braun, B. Meder, C. Reich, M. Arsalan, T. Holubec, T. Walther, F. Emrich, J. Krishnan, A. M. Zeiher,  D.John, Dimmeler S. Nat Cardiovasc Res. 2022. 1:174–185

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S. Nat Commun. 2021 Jan 29;12(1):681. doi: 10.1038/s41467-021-20905-1.

Single Nuclei Sequencing Reveals Novel Insights Into the Regulation of Cellular Signatures in Children With Dilated Cardiomyopathy.

Nicin L, Abplanalp WT, Schänzer A, Sprengel A, John D, Mellentin H, Tombor L, Keuper M, Ullrich E, Klingel K, Dettmeyer RB, Hoffmann J, Akintuerk H, Jux C, Schranz D, Zeiher AM, Rupp S, Dimmeler S. Circulation. 2021 Apr 27;143(17):1704-1719.

Post-myocardial infarction heart failure dysregulates the bone vascular niche.

Hoffmann J, Luxán G, Abplanalp WT, Glaser SF, Rasper T, Fischer A, Muhly-Reinholz M, Potente M, Assmus B, John D, Zeiher AM, Dimmeler S.  Nat Commun. 2021 Jun 25;12(1):3964. doi: 10.1038/s41467-021-24045-4.

Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.

Abplanalp WT, Cremer S, John D, Hoffmann J, Schuhmacher B, Merten M, Rieger MA, Vasa-Nicotera M, Zeiher AM, Dimmeler S. Circ Res. 2021 Jan 22;128(2):216-228. 

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition.

Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4180-4187

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. 

Neumann P, Jaé N, Knau A, Glaser SF, Fouani Y, Rossbach O, Krüger M, John D, Bindereif A, Grote P, Boon RA, Dimmeler SNat Commun. 2018 Jan 16;9(1):237. doi: 10.1038/s41467-017-02431-1

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.

Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Chen W, Schwalbe H, Bindereif A, Eriksson P, Maegdefessel L, Hedin U, Zeiher AM, Dimmeler SNat Med. 2016

MicroRNA-34a regulates cardiac ageing and function.

Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Horrevoets AJ, Didier N, Girmatsion Z, Bonauer A, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S.
Nature 2013; 49574392013Mar7: 107-10

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.

Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S.
Nature cell biology 2012; 1432012: 249-56

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.

Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM, Dimmeler S. Science (New York, N.Y.) 2009; 32459352009Jun26: 1710-3

Cathepsin L is required for endothelial progenitor cell-induced neovascularization.

Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, , Abolmaali ND, Chavakis E, Reinheckel T, Pennacchio LA, Zeiher AM, Dimmeler S. Nature medicine 2005; 1122005Feb: 206-13

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells.

Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM, Dimmeler S.
Nature medicine 2003; 9112003Nov: 1370-6

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.

Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM,  Dimmeler S
Nature 1999; 39967361999Jun10: 601-5