General scientific objectives:
Epigenetic regulation of gene expression was shown to be involved in many biological processes, including embryonic development and disease conditions. Jumonji C (JmjC) domain-containing proteins have been described as histone demethylases that alter chromatin accessibility and hereby regulating gene transcription. Previous studies implicate an important function of JmjC domain-containing proteins in endothelial cell differentiation, but their function in mature endothelial cells and during endothelial cell dependent functions, such as angiogenesis are largely unknown. Therefore our studies focus on the elucidation of JmjC domain-containing protein functions in the endothelium by using gain- and loss of function approaches in vitro and in vivo.