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Research Topics

miRNAs in Vascular Biology

Non-coding RNAs, especially microRNAs (miRs), intracellularly control posttranscriptional gene expression by modulating mRNA stability or translation and thereby regulating cell functions. Additionally, miRs are able to act as cell-to-cell communication signals since they are released and can be taken up by cells. >>

miRNA Processing

MicroRNAs are small non-coding RNAs that post-transcriptionally control gene expression. We and others have demonstrated that individual members of the miR-17~92 cluster specifically control endothelial cell functions. >>

Epigenetics

Cell fate and function is regulated by epigenetics mechanisms including histone modifications. We aim to identify mechanisms controlling cell fate decisions and self renewal in order to generate vascular of the injured heart. >>

Cell therapy

Cell therapy is a promising option to treat patients with cardiovascular diseases. We previously establish the cell therapy of acute and chronic ischemic patients with bone marrow-derived mononuclear cells. >>

Molecular Angiogenesis

We have focused our research on the analysis of microRNAs and histone deacetylases (HDAC). MiRNAs are small RNA molecules that regulate gene expression at the post-transcriptional level. >>

Expert technical support

Expert technical support >>

Cardiovascular Aging

We aim to unravel the role of non-coding RNAs in the process of aging of the cardiovascular system. Both long and short (microRNAs) non-coding RNAs are emerging as key regulatory factors of virtually all cellular and physiological processes. We particularly focus on the effects of aging on apoptosis and dysfunction of cardiomyocytes, smooth muscle cells and endothelial cells. >>

Cardiovascular Bioinformatics

Using the power of computers, we aim to uncover the epigenetic control of tissue development and cell differentiation by focusing on the involvement of long noncoding RNAs. We are equipped with both dry and wet labs not only to develop bioinformatics tools but also to test these tools by biological experiments to validate our predictions over computers. >>

Integrin Signalling Group

Our group is studying the mechanisms regulating integrin function in endothelial cells and their contribution to endothelial cell migration and angiogenesis. Indeed, we are focusing on proteins regulating β1-Integrins integrin affinity in endothelial cells and are studying their role in vascular formation. >>

Vascular Inflammation Group

Vascular inflammation is a multifactorial pathophysiological process characterized by platelet activation, chemokine/cytokine secretion, cell-cell interaction, and immune cell recruitment on vascular wall. Vascular inflammation is involved in a plethora of vascular diseases including coronary heart disease, acute myocardial infarction, stroke and peripheral vascular disease, often leading to organ failure. >>

LncRNAs in Cardio-pulmonary Development

Embryogenesis and resultant organ development is a tightly controlled process intrinsically programmed into the genomes of organisms. During mid-gestation mouse development, the embryo develops all of the structures, anlagen, and cell-types that are required to form a fully-functional organism. >>