 MicroRNAs comprise small non-coding RNAs that posttranscriptionally control gene expression by modulating mRNA stability or translation. We aim to identify microRNAs, which are regulated by cardiovascular disease and aging, in order to develop novel therapeutic approach for cardiovascular repair. >>
| MicroRNAs are small non-coding RNAs that post-transcriptionally control gene expression. We and others have demonstrated that individual members of the miR-17~92 cluster specifically control endothelial cell functions. >> |
 Cell fate and function is regulated by epigenetics mechanisms including histone modifications.
We aim to identify mechanisms controlling cell fate decisions and self renewal in order to generate vascular of the injured heart. >>
| Cell therapy is a promising option to treat patients with cardiovascular diseases. We previously establish the cell therapy of acute and chronic ischemic patients with bone marrow-derived mononuclear cells. >> |
 We aim to unravel the role of microRNAs in the process of aging of the cardiovascular system. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression and are emerging as key regulatory factors of virtually all cellular and physiological processes. >>
|  Our group is studying the mechanisms regulating integrin function in endothelial cells and their contribution to endothelial cell migration and angiogenesis. Indeed, we are focusing on proteins regulating β1-Integrins integrin affinity in endothelial cells and are studying their role in vascular formation. >>
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 Our research program is devoted to the analysis of the transcriptional circuits governing the growth, maintenance and regression of blood vessels in development and disease. We have focused our efforts on the analysis of Notch signaling and Foxo transcription factors, two critical transcriptional regulators of blood vessel growth and homeostasis, as well as their regulation by reversible acetylation. >>
|  Vascular inflammation is a multifactorial pathophysiological process characterized by platelet activation, chemokine/cytokine secretion, cell-cell interaction, and immune cell recruitment on vascular wall. Vascular inflammation is involved in a plethora of vascular diseases including coronary heart disease, acute myocardial infarction, stroke and peripheral vascular disease, often leading to organ failure. >>
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